Increased Intrinsic Excitability of Muscle Vasoconstrictor Preganglionic Neurons May Contribute to the Elevated Sympathetic Activity in Hypertensive Rats Running Heading: Reduced I a in Sympathetic Preganglionic Neurons of Sh Rat 4
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چکیده
1 School of Physiology & Pharmacology, Medical Sciences Building, University Walk, University 7 of Bristol, Bristol, BS8 1TD, UK. 2 Department of Anaesthesia, University Hospitals Bristol, 8 Bristol, BS2 8HW, UK. 3 Department of Engineering Mathematics, Merchant Venturers Building, 9 Woodland Road, University of Bristol, Bristol, BS8 1UB, UK. 4 Centre for Integrative Physiology, 10 University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD 11 12 Author contributions: 13
منابع مشابه
Increased intrinsic excitability of muscle vasoconstrictor preganglionic neurons may contribute to the elevated sympathetic activity in hypertensive rats
Hypertension is associated with pathologically increased sympathetic drive to the vasculature. This has been attributed to increased excitatory drive to sympathetic preganglionic neurons (SPN) from brainstem cardiovascular control centers. However, there is also evidence supporting increased intrinsic excitability of SPN. To test this hypothesis, we made whole cell recordings of muscle vasocons...
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Cocaine and amphetamine-regulated transcript peptide (CART) is present in a subset of sympathetic preganglionic neurons in the rat. We examined the distribution of CART-immunoreactive terminals in rat stellate and superior cervical ganglia and adrenal gland and found that they surround neuropeptide Y-immunoreactive postganglionic neurons and noradrenergic chromaffin cells. The targets of CART-i...
متن کاملSpecific respiratory neuron types have increased excitability that drive presympathetic neurones in neurogenic hypertension.
A major aspect of hypertension is excessive sympathetic activity but the reasons for this remain elusive. Sympathetic tone is increased in the spontaneously hypertensive (SH) rat reflecting, in part, enhanced respiratory-sympathetic coupling. We aimed to identify which respiratory cells might have altered properties. Using the working heart-brain stem preparation, we monitored simultaneously sy...
متن کاملOn the Number of Preganglionic Neurons Driving Human Postganglionic Sympathetic Neurons: A Comparison of Modeling and Empirical Data
Postganglionic sympathetic axons in awake healthy human subjects, regardless of their identity as muscle vasoconstrictor, cutaneous vasoconstrictor, or sudomotor neurons, discharge with a low firing probability (∼30%), generate low firing rates (∼0.5 Hz) and typically fire only once per cardiac interval. The purpose of the present study was to use modeling of spike trains in an attempt to defin...
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تاریخ انتشار 2014